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Experiment 1 : Cells were treated with increasing concentrations of FFAs (0.25, 0.5, and 1.0 mM), lipopolysaccharides or tumor necrosis factor- for 24 h or were treated with FFAs (0.5 mM) at different times (12, 24, 36, and 48 h)

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The key takeaway from human genetic and epigenetic data is that the NNMT axis is biologically active and relevant to human metabolism